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Research and Development

Our ultimate research goal is to develop a toxicity evaluation system to link sentinel/indicator organism’s biological (morphological/physiological) responses and molecular (genomic/transcriptomic) responses, which are influenced by environmental stress, toxic chemicals, food, etc. By supplying our EG microarray products and gene expression analysis services, we have been promoting transcriptomics (gene expression study) in our research collaboration activities in the fields of environmental toxicology, pharmacology, and functional food research.

Our research subjects with DNA microarray applications are as follows:
  1. Toxicogenomics research of EDC (Endocrine Disrupting Chemicals) and other newly emerging environmentally toxic chemicals such as PPCPs(Pharmaceuticals and Personal Care Products).

  2. Trial use of DNA microarray gene expression analysis in WET (Whole Effluent Toxicity) test using Japanese medaka and zebrafish embryos and eleutheroembryos.

  3. Chemical-specific biomarker search in fish and rodent organs or tissues.

  4. Nutrigenomics research – functionality assessment of food and food component

Published research papers:
  1. Aquatic Toxicity and Ecological Risk Assessment of Seven Parabens: Individual and Additive Approach.
    Yamamoto H. et al. Sci. Total Env. 2011; in press.

  2. Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook
    Van Aggelen G. et al. Environ. Health Perspect. 2010; 118(1): 1–5.

  3. Estrogenic effects of o,p'-DDT exposure in Japanese medaka (Oryzias latipes).
    Uchida M., et al. J. Toxicol. Sci. 2010; 35(4): 605-608.

  4. Changes in gene expression profile of medaka with acute toxicity of Arochlor 1260, a polychlorinated biphenyl mixture.
    Yum S. et al. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 2010; 151(1): 51-56.

  5. Preliminary ecological risk assessment of butylparaben and benzylparaben -1. Removal efficiency in wastewater treatment, acute/chronic toxicity for aquatic organisms, and effects on medaka gene expression.
    Yamamoto H. et al. Environ. Sci. 2007; 14 Suppl: 73-87.